Indianapolis Colts rule out star RB Jonathan Taylor for game at Denver Broncos due to ankle injury play Can the Colts get on track against the Broncos? (1:24) Dan Orlovsky breaks down what the Colts need to do in order to ensure a win in Denver. (1:24) 1:27 PM ET Stephen HolderESPN INDIANAPOLIS -- Colts All-Pro running back Jonathan Taylor will miss the first game of his college or pro career after being ruled out for Thursday night's road contest against the Denver Broncos . Taylor sustained a badly twisted ankle late in the Colts' 24-17 loss to the Tennessee Titans last Sunday and did not return to the game. He had been undergoing constant rehab since in an effort to make it back for Thursday night, even suggesting on Tuesday that a decision on his availability might come shortly before kickoff. But, in the end, the third-year back was unable to overcome the injury. Editor's Picks Predicting Week 5 upsets, whose 3-1 start won't hold up, and what's next in Washington: NFL buzz 4h Jeremy Fowler and Dan Graziano Colts RB Taylor hopes to play despite ankle injury 5h Stephen Holder 2 Related "I definitely do plan to play, but if you can't go you can't go," Taylor said Tuesday. "That's why you have to get as much treatment as you can." The Colts have been struggling to generate a consistent running game even with Taylor in the lineup, so his absence will not make things any easier. The Colts enter Week 5 at 27th in rushing yards per game (87.8) and per carry (3.5), a far cry from last season when Taylor was the NFL's leading rusher with 1,811 yards and the Colts led the league in rushing. The Colts will lean on some combination of carries from No. 2 running back Nyheim Hines , Deon Jackson and, possibly, former Broncos star Phillip Lindsay , who is on their practice squad. The Colts also ruled out linebacker Shaquille Leonard and defensive lineman Tyquan Lewis with concussions and safety Julian Blackmon with an ankle injury.