49ers WR Deebo Samuel carted off in first half vs. Buccaneers 6:17 PM ET Nick WagonerESPN Staff Writer Close Covered Rams for nine years for stlouisrams.com Previously covered University of Missouri football Member of Pro Football Writers of America SANTA CLARA, Calif. -- For the second week in a row, the San Francisco 49ers appeared to have suffered a significant injury to a key offensive player in the first half. Receiver Deebo Samuel departed Sunday's game against the Tampa Bay Buccaneers with a left knee injury with about five minutes left in the second quarter. On second-and-9 at Tampa's 43, Samuel took a handoff from quarterback Brock Purdy and ran up the middle. As a pair of Buccaneers defenders converged on Samuel, he attempted to spin out and appeared to get his left knee twisted in an awkward direction. Samuel lost the ball as Tampa recovered but stayed down for a few minutes in obvious pain. Most of the 49ers roster quickly ran on the field to be close to Samuel as the medical staff checked on him and San Francisco fans chanted "Dee-bo, Dee-bo" in an effort to will him back to health. Editor's Picks 49ers: 'Way outside chance' of Garoppolo return 3d Nick Wagoner 2 Related Samuel briefly stood up and appeared set to hobble to the sideline with some help from medical staff but dropped back to the ground and yelled an expletive picked up by the officials' microphone. A cart came out soon after, taking a dejected Samuel to the locker room. Samuel had his hands on his left knee and his head down as the cart disappeared into the Niners' tunnel. Initially, the 49ers announced that Samuel was questionable to return but they ruled him out soon after. Samuel's injury comes a week after quarterback Jimmy Garoppolo suffered a broken left foot that is expected to keep him out for the rest of the season. Samuel had four catches for 43 yards and four carries for 21 yards and a touchdown at the time of his injury. San Francisco led, 28-0, at the half.