49ers starting RB Mitchell suffers injury to knee

by Ricardo Gutierrez - 49ers RB Elijah Mitchell has suffered a knee injury and won't return to Sunday's game against the Bears.

San Francisco 49ers starting RB Elijah Mitchell suffers injury to knee 2:42 PM ET Nick WagonerESPN Staff Writer Close Covered Rams for nine years for stlouisrams.com Previously covered University of Missouri football Member of Pro Football Writers of America CHICAGO -- For the second consecutive year, the San Francisco 49ers starting running back departed the season opener with a knee injury. Niners starter Elijah Mitchell departed Sunday's game against the Chicago Bears with a knee ailment just before halftime. It wasn't immediately clear how Mitchell got hurt, though his last snap before the injury was receiver Deebo Samuel 's 6-yard touchdown run with 10:11 left in the first half. Mitchell was blocking on the outside for Samuel on the play and it appeared a Bears defender rolled into the back of his legs. Mitchell had six carries for 41 yards before exiting. Entering his second NFL season, Mitchell has dealt with myriad injuries, including a hamstring injury that kept him out of the preseason. In 2021, he set a franchise rookie rushing record with 963 yards, adding five touchdowns despite missing six games with multiple injuries (ribs, knee, finger, shoulder and concussion). With Mitchell out, Jeff Wilson Jr . stepped into the primary running back role with rookie Jordan Mason as the backup. Tyrion Davis-Price , a third-round pick out of LSU, was a pregame inactive but is also on the 53-man roster. Mitchell's injury comes almost a year to the day after Niners starting running back Raheem Mostert left the 2021 season opener against the Detroit Lions with a knee injury of his own. Mostert missed the rest of the season before signing with the Miami Dolphins in the offseason.