49ers RBs McCaffrey, Mitchell to sit out practice

by Ricardo Gutierrez - 49ers running backs Christian McCaffrey (bruised calf) and Elijah Mitchell (groin) will sit out Wednesday's session.

49ers RBs McCaffrey, Mitchell to sit out practice play Stephen A.: Eagles' best chance of beating 49ers comes down to Hurts (1:42) Stephen A. Smith argues that the 49ers-Eagles matchup is so evenly matched that the game will come down to how Jalen Hurts and Brock Purdy perform. (1:42) 4:20 PM ET Nick WagonerESPN Staff Writer Close Covered Rams for nine years for stlouisrams.com Previously covered University of Missouri football Member of Pro Football Writers of America SANTA CLARA, Calif. -- The San Francisco 49ers ' top two running backs will not practice Wednesday as they deal with various injury issues. Running backs Christian McCaffrey (bruised calf) and Elijah Mitchell (groin) will sit out Wednesday's session, according to Kyle Shanahan. Shanahan also said Deebo Samuel (ankle) would sit out Wednesday's session, but the star wide receiver was in uniform for the early portion of Wednesday's practice that was open to media. While Shanahan made no promises about the trio's availability for Sunday's NFC Championship Game against the Philadelphia Eagles , he expressed confidence that all will be ready to go. Editor's Picks Omenihu in line to play for Niners despite arrest 5m Nick Wagoner Bengals or Chiefs? 49ers or Eagles? We're on to the AFC and NFC title games with early previews 2d Brooke Pryor and Seth Walder 2 Related "I expect them to but there's no guarantees, especially with it being the NFC Championship Game," Shanahan said. "I think there's a better chance they'll be ready since there's nothing guaranteed after this. So, hopefully. We'll keep our fingers crossed." McCaffrey and Mitchell's injuries were first mentioned by Shanahan on Monday. He said then he wasn't expecting either ailment to keep McCaffrey or Mitchell from playing against the Eagles. But in the interest of caution, the Niners' two top backs are sitting out Wednesday. After the 19-12 NFC divisional-round victory against the Dallas Cowboys , McCaffrey said he was feeling the bruised calf late in the game but he, too, was mostly unconcerned about it. "I was fighting but made it through," McCaffrey said. "Made it through great. But nothing bad. All good. " Samuel was a new addition to the injury report on Wednesday. Shanahan indicated Samuel has been dealing with the ankle issue for "a little bit." For his part Samuel said there's no doubt in his mind he'll be ready to go against the Eagles. "It's just kind of sore," Samuel said. "We're just being cautious and just trying to get ready for Sunday." Elsewhere on the injury report, quarterback Jimmy Garoppolo had another X-ray on his broken left foot this week. Shanahan said last week there was an "outside chance" Garoppolo could return to practice this week. But that will not happen, which means a Garoppolo return would only occur if the Niners advance to the Super Bowl. Elsewhere on the injury report, defensive lineman Charles Omenihu (oblique) and cornerback Ambry Thomas (ankle) are expected to be limited participants.